The Immune Tolerance Network is headed by over 70 world-leaders in the clinical and basic science of immune tolerance, from academic research institutes around the world. The scientific leadership of the ITN is responsible for setting overall ITN policy, review of scientific proposals and scientific priority setting.

The Network Steering Committee, or NSC, is the main decision-making body of the ITN, with input from both the Industry and International Advisory Committees. A number of other subcommittees address certain administrative tasks, while scientific panels, or “subgroups” assist with the review of proposals and priorities within specific scientific areas.

ITN staff assist the scientific personnel with a number of responsibilities, most notably in the development, implementation and analysis of clinical trials and tolerance assay studies. The ITN Clinical Trials Group acts as a fully functioning clinical research organization (CRO) to carry out ITN trials. Throughout the ITN, numerous links are in place to government organizations like the NIH and FDA.