Antigen-Specific Tolerance Assays
The ITN is seeking proposals for assays to measure antigen-specific responses in samples collected from ITN trials. We will prioritize assays that envision cross-disciplinary utility; which can be applied to transplantation allo-antigen recognition, autoimmune antigen activation, as well as allergen responses. Selected respondents will be provided funding and samples from the ITN biorepository for assay development and validation, analyzed in partnership with ITN scientists.
Full details are included in the RFP. Proposals should be submitted to Philip Bernstein, Executive Director of Strategic Review, Planning, and Communications (firstname.lastname@example.org), by December 1, 2015.
Clinical Trials of Immune Tolerance for Protein/Gene-replacement Therapy
The ITN is currently inviting proposals for novel clinical trials with the aim of inducing tolerance in patients who receive gene/protein-replacement (e.g. hemophilia, Gaucher’s disease) or other exogenous protein therapy, in which the patients are at risk for developing an immune response to the biologic agent. The ideal proposal would have a testable mechanism of tolerance induction and a strategy for assays investigating this mechanism.
Full details are included in the RFP. Proposals should be submitted to Philip Bernstein, Executive Director of Strategic Review, Planning, and Communications (email@example.com), by November 30th, 2015.
Clinical Trials in Immune Tolerance
The ITN accepts Concept Proposals year-round for novel clinical trials with testable hypotheses that are designed to induce immune tolerance in allergy and asthma, autoimmune disease, transplantation and type 1 diabetes. In addition, the ITN accepts proposals for the development of novel tolerance assays or mechanistic studies for the purposes of establishing new surrogate biomarkers of immune tolerance and investigating the mechanisms of clinical tolerance.
Information about the ITN’s approach to tolerance in each therapeutic area (allergy, autoimmune disease, type 1 diabetes and solid organ transplantation) can be found here.
Concept Proposal guidelines and templates can be found here.