Current RFPs

Request for Proposals – Specimens and Funding for Type 1 Diabetes Biomarker Research

Creating durable disease remission in type 1 diabetes has proved challenging: etiology remains uncertain and immune interventions have only been able to delay disease progression temporarily. To better understand underlying disease pathways, the ITN conducts sophisticated mechanistic assays on high-quality specimens collected from each of its clinical trials. After a study is complete, unused mechanistic specimens are available to the scientific community for further research through the ITN’s Clinical Trials Research Portal, TrialShare.

These specimens represent a rich resource, and The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) has issued a Funding Opportunity Announcement (FOA) for biomarker research using samples from ITN and other NIH-sponsored type 1 diabetes trials.

Deadline: April 10, 2014

Detailed information and instructions: RFP - Research Using Biosamples from Selected Type 1 Diabetes Clinical Studies (DP3)


Request for Proposals – Autoreactive B Cell Assay for Use in the CALIBRATE Study

The ITN is currently seeking Concept Proposals for a mechanistic assay for use in the CALIBRATE study. The assay should reproducibly detect statistically significant differences in the proportion of autoreactive B cells between patients with autoimmune disease and healthy controls or patients following different treatment regimens or with different disease treatment status.

Deadline: March 1, 2014

Detailed information and instructions: RFP - Autoreactive B Cell Assay for Use in CALIBRATE Study


Clinical Trials in Immune Tolerance

The ITN  is currently seeking Concept Proposals for novel clinical trials designed to induce immune tolerance in transplantation, autoimmune diseases and allergy and asthma. In addition, the ITN accepts applications for the development of novel tolerance assays or mechanistic studies for the purposes of establishing new surrogate biomarkers of immune tolerance and investigating the mechanisms of clinical tolerance.

Proposals should be submitted via our website: www.immunetolerance.org/submit-a-proposal

Detailed information and instructions: RFP - Clinical Trials in Immune Tolerance

More Information: 

Research applications to the ITN are not limited to the RFPs seen here.The ITN accepts "Concept Proposals" year-round through it's always-open call for proposals. Visit the Proposals page for more information.