Current RFPs

Clinical Trials in Immune Tolerance

The ITN  is currently seeking Concept Proposals for novel clinical trials designed to induce immune tolerance in allergy and asthma, autoimmune disease, transplantation, and type 1 diabetes. In addition, the ITN accepts applications for the development of novel tolerance assays or mechanistic studies for the purposes of establishing new surrogate biomarkers of immune tolerance and investigating the mechanisms of clinical tolerance.

Proposals should be submitted via our website:

Detailed information and instructions: RFP - Clinical Trials in Immune Tolerance

Request for Proposals – Clinical Trials of Immune Tolerance in Transplantation using Deceased-Donor Organs

The ITN is currently seeking proposals for clinical tolerance trials in transplantation using solid organs or islets from deceased donors. Proposals should meet the following criteria:

  1. There is strong support with preclinical data and/or evidence from clinical pilot studies - if  preclinical studies alone are used to support the proposal, these studies should include brain dead donors or discuss why such studies are not needed with the proposed protocol.
  2. The donor and recipient are HLA mismatched.
  3. Biomarker use and/or discovery should be incorporated into the immunosuppression withdrawal plan.

Deadline: August 29, 2014

Detailed information and instructions: RFP - Transplantation Using Deceased-Donor Organs


More Information: 

Research applications to the ITN are not limited to the RFPs seen here.The ITN accepts "Concept Proposals" year-round through it's always-open call for proposals. Visit the Proposals page for more information.