Proposal Guidelines

Clinical Trials: The Immune Tolerance Network (ITN) accepts applications for novel clinical trials from all interested scientists from academia, industry and government, in the areas of:

  • Kidney & Liver Transplantation
  • Autoimmune Diseases
  • Allergy & Asthma

Assays & Biomarkers: In addition, the ITN accepts applications for the development of novel tolerance assays or mechanistic studies for the purposes of establishing new surrogate markers of immune tolerance and investigating the mechanisms of clinical tolerance. For example, the ITN will consider proposals that seek to better understand clinical tolerance by utilizing ITN tolerance assay resources in existing or planned clinical trials that are funded through other sources.

The ITN does NOT accept proposals for non-human or preclinical studies.


The Application Process

The ITN application process is a two-stage process designed to fast-track applications from proposal to protocol development. Applicants submit a short (~5-page) Concept Proposal containing a basic outline and justification of the proposed research. Applicants whose proposals are of interest to the ITN will then be asked to submit a more complete Full Application for review.

There is no deadline for submission of Concept Proposals; they are accepted throughout the year with reviews taking place several times per year.

Applicants should note that the ITN review process differs significantly from traditional study section reviews by maintaining a much more interactive method designed to assist potential investigators in the preparation of highly focused, relevant scientific proposals. The number of projects funded and the total available funding varies from year to year.

Complete guidelines and forms are available for download below.

More Information: 


Concept Proposal Guidelines - PDF
Complete guidelines on the submission and review of Concept Proposals

Clinical Trial Proposal Template Form - MS Word
Complete and submit this form to propose a clinical trial (new applications only).

Tolerance Assay Proposal Template Form - MS Word
Complete and submit this form to propose an assay or biomarker study (new applications only).

Revised Proposal Template Form - MS Word
Complete and submit this form if you are responding to an ITN request for a revised proposal.

TrialShare Sample Request Proposal- MS Word
Complete and submit this form if you are requesting the use of ITN samples. To view available samples, visit www.ITNTrialShare.org.