A clinical research consortium sponsored by NIAID and JDRF

Clinical Trials

Active

Promoting Tolerance to Peanut in High-Risk Children (LEAP)

Principal Investigator:
Gideon Lack, Evelina Children's Hospital, London, UK

Promoting Tolerance to Common Allergens in High-Risk Children: Global Prevention of Asthma in Children (GPAC) Study

Principal Investigator:
Patrick Holt, University of Western Australia, Perth, AUS
Peter Sly, Telethon Institute for Child Health Research, Perth, AUS

Campath-1H/Tacrolimus/Sirolimus Withdrawal in Renal Transplantation

Principal Investigator:
Stuart Knechtle, University of Wisconsin, Madison, WI

Belatacept to Prevent Organ Rejection in Kidney Transplant Patients

Principal Investigator:
Flavio Vincenti, University of California, San Francisco, CA
Christian Larsen, MD, Emory University, Atlanta, GA

Gradual Withdrawal of Immunosuppression in Patients Receiving a Liver Transplant (AWISH)

Principal Investigator:
Abraham Shaked, University of Pennsylvania, Philidelphia, PA

Immunosuppression Withdrawal for Pediatric Living-Donor Liver Transplant Recipients (WISP-R)

Principal Investigator:
Sandy Feng, University of California, San Francisco

Study of Thymoglobulin to Arrest Type 1 Diabetes (START)

Principal Investigator:
Stephen Gitelman, University of California, San Francisco

A Phase I Trial of IL-2 and Sirolimus in Recent-onset Type 1 Diabetes Mellitus

Principal Investigator:
Carla Greenbaum, Virginia Mason Research Center

ITN Registry of Tolerant Kidney Transplant Recipients

Principal Investigator:
Kenneth Newell, Emory University

Cytokine production in blood leukocytes of prediabetic children and effect of intranasal insulin

Principal Investigator:
Jorma Ilonen, University of Turku, Finland

Abatacept and Cyclophosphamide Combination: Efficacy and Safety Study (ACCESS) for Lupus Nephritis

Principal Investigator:
David Wofsy, University of California San Francisco, CA
Betty Diamond, Feinstein Institute, Manhasset, NY

High dose immunosuppression and autologous transplantation for multiple sclerosis (HALT MS)

Principal Investigator:
Richard A. Nash, Fred Hutchinson Cancer Research Center, Seattle, WA

Renal Allograft Tolerance through Mixed Chimerism

Principal Investigator:
David H. Sachs, MD, Harvard Medical School

A Screening Study for Identification of Tolerance Markers in Liver Transplant Recipients Who Received Campath-1H Immunosuppressi

Principal Investigator:
Andreas Tzakis, MD, Jackson Memorial Hospital
Panagiotis Tryphonopoulos, MD, University of Miami

Completed

Multicenter trial of islet transplantation in type 1 diabetic patients using the Edmonton protocol

Principal Investigator:
James Shapiro, University of Alberta, Edmonton, Canada

Allergen ISS conjugates in allergic rhinitis

Principal Investigator:
Peter Creticos, Johns Hopkins University, Baltimore, MA

Renal allograft tolerance through mixed chimerism

Principal Investigator:
David H. Sachs, Mass. General Hospital, Boston, MA
A. Benedict Cosimi, Mass. General Hospital, Boston, MA

Autoantigen vaccination in newly diagnosed type 1 diabetes mellitus

Principal Investigator:
Tihamer Orban, Joslin Diabetes Center, Boston, MA

Phase I study of the treatment of multiple sclerosis with CTLA4Ig

Principal Investigator:
Samia Khoury, Brigham & Women's Hospital, Boston, MA

Rituximab for the Treatment of Wegener's Granulomatosis and Microscopic Polyangiitis (RAVE)

Principal Investigator:
John H. Stone, Johns Hopkins University
Ulrich Specks, Mayo Clinic