Latest News

As you may have noticed, the ITN website has undergone some pretty majorchanges. We hope you enjoy the new look and will find the new site easier tonavigate and as informative as our previous versions. Our website has gone through several iterations since the ITN was founded in 1999. Prior to this redesign, the last revision took place in May 2002, whenthe ITN was still relatively young and was conducting only a handful of clinical trials.

A phase I study of costimulatory blocking agent CTLA4Ig shows that the treatment appears safe for use in multiple sclerosis and that it can induce favorable immunologic changes. Results from the ITN-led study were published in the September 16, 2008 issue of the peer-reviewed journal Neurology. A total of 20 relapsing-remitting MS subjects were enrolled in the phase 1 dose escalation study of intravenous CTLA4Ig infusions, conducted at Brigham & Women's Hospital under the direction of principal investigator Samia J. Khoury, MD.

Subject enrollment in the ITN's study of immunosuppression withdrawal in pediatric liver transplantation was completed this month, with the enrollment of the 20th and final subject.The study, led by University of California San Francisco transplant surgeon Sandy Feng, MD, aims to identify immunologic or genetic tests indicating that a patient may be safely removed from immunosuppressive therapy following liver transplantation.