Aly TA, Eller E, Ide A, Gowan K, Babu SR, Erlich HA, Rewers MJ, Eisenbarth GS, and Fain PR. Multi-SNP analysis of MHC region: Remarkable conservation of HLA-A1-B8-DR3 haplotype. Diabetes 55:1265-1269, 2006. [PubMed] [Reprint]

Aly TA, Ide A, Jahromi MM, Barker JM, Fernando MS, Babu SR, Yu L, Miao D, Erlich HA, Fain PR, Barriga KJ, Norris JM, Rewers MJ, and Eisenbarth GS. Extreme genetic risk for type 1A diabetes. Proc Natl Acad Sci. 103:14074-14079, 2006. [PubMed] [Reprint]

Casale, TB, Busse WW, Kline JN, Ballas ZK, Moss MH, Townley RG, Mokhtarani M, Seyfert-Margolis V, Asare A, Bateman K, Deniz Y, Immune Tolerance Network. Omalizumab Pretreatment Decreases Acute Reactions Following Rush Immunotherapy for Ragweed-Induced Seasonal Allergic Rhinitis. J Allergy Clin Immunol 117: 134-140, 2006. [PubMed] [Reprint]

Creticos PS, Schroeder JT, Hamilton RG, Alcer-Whaley SL, Bhattignavong AP, Lindblad R, Hoffman R, Seyfert V, Eiden JJ, Broide D, Immune Tolerance Network Group (2006): Immunotherapy with a Ragweed–Toll-Like Receptor 9 Agonist Vaccine for Allergic Rhinitis.  New Engl J Med 355: 1445-1455, 2006. [PubMed] [Reprint]

Derks RA, Jankowska-Gan E, Xu Q, Burlingham WJ. Dendritic cell type determines the mechanism of bystander suppression by adaptive T regulatory cells specific for the minor antigen HA-1. J Immunol 179: 3443-51, 2007. [PubMed] [Reprint]

Fudaba Y, Spitzer TR, Shaffer J, Kawai T, Fehr TI, Delmonico F, Preffer F, Tolkoff-Rubin N, Dey B, Saidman SL, Kraus A, Bonnefoix T, McAfee S, Kattleman K, Colvin RB, Sachs DH, Cosimi AB, Sykes M. Myeloma responses and tolerance following combined kidney and non-myeloablative marrow transplantation: in vivo and in vitro analyses.  Am J Transplant 6: 2121-2133, 2006. [PubMed] [Reprint]

Kawai, T, Cosimi AB, Spitzer TR, Tolkoff-Rubin, N, Suthanthiran M, Saidman SL, Shaffer J, Preffer FI, Ding R, Sharma V, Fishman JA, Dey B, Ko DSC, Hertl M, Goes NB, Wong W, Williams WW, Colvin RB, Sykes M, Sachs DH. HLA-Mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 358: 353-61, 2008 [PubMed] [Reprint]

Klunker S, Saggar LR, Seyfert-Margolis V, Asare AL, Casale TB, Durham SR, Francis JN; Immune Tolerance Network Group. Combination treatment with omalizumab and rush immunotherapy for ragweed-induced allergic rhinitis: Inhibition of IgE-facilitated allergen binding. J Allergy Clin Immunol 120: 688-95, 2007. [PubMed] [Reprint]

Seyfert-Margolis V, Gisler TD, Asare AL, Wang RS, Dosch HM, Brooks-Worrell B, Eisnenbarth GS, Palmer JP, Greenbaum CJ, Gitelman SE, Nepom GT, Bluestone JA, Herold KC. Analysis of T cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled study. Diabetes 55: 2588-94, 2006. [PubMed] [Reprint]

Shamji MH, Wilcock LK, Wachholz PA, Dearman RJ, Kimber I, Wurtzen PA, Larché M, Durham SR, Francis JN. The IgE-facilitated allergen binding (FAB) assay: validation of a novel flow-cytometric based assay for the detection of inhibitory antibody responses. J Immunol Meth 317: 71-9, 2006. [PubMed] [Reprint]

Shapiro AMJ, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, Secchi A'Brendel MD, Berney T, Brennan DC, Cagliero E, Alejandro R, Ryan EA, DiMercurio B, Morel P, Polonsky KS, Reems J, Bretzel RG, Bertuzzi F, Froud T, Kandaswamy R, Sutherland DER, Eisenbarth G, Segal M, Preksaitis J, Korbutt GS, Barton FB, Viviano L, Seyfert-Margolis V, Bluestone J, and Lakey JRT (2006): International Multicenter Trial of Islet Transplantation with the Edmonton Protocol in Type 1 Diabetes.  New Engl J Med 355: 1318-1330, 2006. [PubMed] [Reprint]

St. Clair EW, Turka LA, Saxon A, Matthews JB, Sayegh MH, Eisenbarth GS, Bluestone J. New reagents on the horizon for immune tolerance. Ann Rev Medicine 58:329–46, 2007. [PubMed] [Reprint]

Vandenbark AA, Culbertson NE. Trivalent T cell receptor peptide vaccine for treatment of multiple sclerosis targets predominant V genes widely implicated in autoimmune diseases and allergy. In: Immune Regulation and Immunotherapy in Autoimmune Disease. Zhang J, ed. Springer Life Sciences, 2007, pp 369-408. [Info]

Vandenbark AA, Culbertson NE, Bartholomew RM, Huan J, Agotsch M, LaTocha D, Yadav V, Mass M, Whitham R, Lovera J, Milano J, Theofan G, Chou YK, Offner H, Bourdette DN. Therapeutic vaccination with a trivalent T-cell receptor (TCR) peptide vaccine restores deficient FoxP3 expression and TCR recognition in subjects with multiple sclerosis. Immunology 123: 66-78, 2008. [PubMed] [Reprint]

Xu Q, Lee J, Jankowska-Gan E, Schultz J, Roennburg DA, Haynes LD, Kusaka S, Sollinger HW, Knechtle SJ, Vanbuskirk AM, Torrealba JR, Burlingham WJ. Human CD4+CD25low Adaptive T Regulatory Cells Suppress Delayed-Type Hypersensitivity during Transplant Tolerance. J Immunol 178: 3983-3995, 2007. [PubMed]

Abstracts

Boyce K, Spencer T. Using automated extract, transform and load (ETL) processes to build an integrated warehouse of clinical and mechanistic results in immunology-based trials. American Medical Informatics Association Symposium Spring Congress, Phoenix, AZ, May 2006. [Poster]

Carreno M, Ciancio G, Burke GW, Cirocco R, Gomez C, Salma F, Mathew J, Jin Y, Miller J, Esquenazi V. Precursor dendritic cell subsets in kidney allograft recipients after induction with alemtuzumab (C1H) vs thymoglobulin (Thy) vs daclizumab (Dac) vs A C1H recipient given donor specific stem cells (DHSC). ASHI 31st Annual Meeting, San Diego, California, October 17, 2006. [Abstract]

Cirocco R, Carreno M, Mathew J, Vallone T, Rosen A, Burke GW, Ciancio G, Kleiner G, Esquenazi V, Miller J. Upregulation of FOXP3 in renal transplantation after antibody induction regimens with and without bone marrow or stem cell infusions. World Transplant Congress, Boston, Massachusetts, July 22, 2006. [Abstract]

Demetris AJ, Ruppert K, Ekong U, Rosenthal P, Sayre P, Tchao N, Feng S. Morphometric and Histopathologic Analysis of Protocol Biopsies from Stable, Long-Surviving Pediatric Recipients of Living-Related Liver Allografts: A Comparison to Liver Age and Sex-Matched Controls [Abstract #909]. American Transplant Congress, San Francisco, CA, May 5-9, 2007. [Abstract]

Francis JN, Wilcock LK, Paraskavopoulos G, Till SJ, Durham SR. Time-course analysis of a Double-Blind Placebo Controlled Trail of Grass Pollen Immunotherapy: increased cellular IL-10 production and reduction in late phase responses precede increased IgG4 and early phase responses. Collegium Internationale Allergologicum, Malta, May 5-10, 2006. [Abstract]

Francis JN, Saggar LR, Seyfert-Margolis V, Asare AL, Klunker S, Casale TB, Durham SR and Immune Tolerance Network Group. The combination of anti-IgE monoclonal antibody (omalizumab) with ragweed immunotherapy results in enhanced and long-term inhibitory effects on facilitated-antigen presentation. XXVI Meeting of the EAACI, Goteborg, Sweden, June 9-13, 2007. [Abstract]

Hernandez-Fuentes MP, Sagoo P, Jimenez-Vera E, Rovis F, Waters J, Hilton R, Warrens AN, Lechler R. Indices of immunological tolerance in renal transplantation: Interim analysis. Poster 48, British Transplantation Society, Edinburgh, March 2006. [Abstract]

Hernandez-Fuentes MP, Sawitszki B, Sagoo P, Flavia R, Jimenez E, , Perucha E, Le Moine A, Craciun L, Peters B, Braudeau C, Brouard S, Trzonkowski P, Warnecke G, Chapman S, Libin M, Warrens A, Goldman M, Volk H-D, Soulillou JP, Janssen U, Wood K, Lechler RI. Indices of tolerance: Interim Report. Abstract #999. World Transplant Congress, Boston, MA, July 2006. Am J Transplant, 2006, (6):s2 p403. [Abstract]

ITN Tolerance Assay and Data Analysis Group, the ITN Clinical Trials Group, and the ITN TILT Study Investigators.Kinetics of Immune Cell Depletion and Reconstitution with Alemtuzumab: A Possible Explanation for Low Incidence of Opportunistic Infections [Abstract #1735]. American Transplant Congress, San Francisco, CA, May 5-9, 2007. [Abstract]

Kawai T, Sachs D, Spitzer T, Tolkoff-Rubin N, Saidman S, WilliamsW, Dey B, Goes N, Ko D, Hertl M, Cotter P, Wong W, Colvin R, Sykes M, Cosimi AB. Successful Induction of Renal Allograft Tolerance in HLA-Mismatched Kidney Transplant Recipients. FASEB Summer Research Conference, Snowmass, Colorado, June 3-8, 2006. [Abstract]

Kawai T, Sachs DH, Spitzer T, Tolkoff-Rubin N, Saidman S, Williams W, Dey B, Goes N, Ko D, Wong W, Colvin RB, Sykes M, Cosimi AB. The Long-Term Evaluation of HLA-Mismatched Combined Kidney and Bone Marrow Transplant Recipients after Complete Withdrawal of Immunosuppression [Abstract #1717]. American Transplant Congress, San Francisco, CA, May 5-9, 2007. [Abstract]

Kawai T, Suthanthiran M, Sharma V, Ding R, Sykes M, Colvin RB, Cosimi AB, Sachs DH. Intragraft RNA Expression of FOXP3 Versus Proinflammatory Cytokines in Tolerant Recipients of HLA Mismatched Renal Allografts [Abstract #2]. American Transplant Congress, San Francisco, CA, May 5-9, 2007. [Abstract]

Klunker S, Francis JN, Casale TB, Durham SR. Anti-IgE Therapy Inhibits IgE-facilitated Allergen Presentation and Increases the Efficacy of Ragweed Immunotherapy. 2006 AAAAI Annual Meeting, Miami, FL., March 3-7. Journal of Allergy and Clinical Immunology Vol. 117 (2) S89: 2006. [Abstract]

Knechtle SJ, Sollinger HW, Jankowska-Gan E, Burlingham WJ, Bloom DJ. Preliminary results of a tolerance trial in renal transplantation. World Transplant Congress, Boston, Massachusetts, July 22. Am J Transplant, 6: s171, 2006 [Abstract]

Knechtle S, Hu H, Janus C, Radke N, Sollinger H, Davis Z, Bloom D. A Tolerance Trial in Kidney Transplantation Based on T-cell Depletion, Tacrolimus, and Sirolimus [Abstract #1724]. American Transplant Congress, San Francisco, CA, May 5-9, 2007. [Abstract]

Mathew J, Carreno M, Cirocco R, Rosen A, Vallone T, Garcia-Morales R, Burke GW, Ciancio G, Esquenazi V, Miller J. Circulating and graft infiltrating regulatory cells in donor stem cell infused kidney transplant patients treated with alemtuzumab. 12th Innovative Therapeutics in Transplantation Meeting, Nantes, France, June 15, 2006. [Abstract]

Mathew J, Cirocco R, Rosen A, Vallone T, Gomez C, Blomberg B, Fuller L, Burke GW, Ciancio G, Esquenazi V, Miller J. Tolerogenicity of graft infiltrating lymphocytes in donor stem cell infused kidney transplant recipients treated with alemtuzumab. ASHI 31st Annual Meeting, San Diego, CA, October 17, 2006. [Abstract]

Mathew J, Vallone T, Carreno M, Garcia-Morales R, Rosen A, Gomez C, Blomberg B, Fuller L, Burke GW, Ciancio G, Esquenazi V, Miller J. Regulatory cells of donor and recipient phenotypes in donor stem cell infused kidney transplant recipients treated with alemtuzumab. World Transplant Congress, Boston, Massachusetts, July 22, 2006. [Abstract]

Nash RA, Openshaw H, Bowen JD, Forman SJ, Stuve O, Hutton G, Popat U, Kraft G. A Phase II Study of High-Dose Immunosuppressive Therapy (HDIT) Using Carmustine, Etoposide, Cytarabine, and Melphalan (BEAM) + Thymoglobulin, and Autologous CD34+ Hematopoietic Stem Cell Transplant (HCT) for the Treatment of Poor Prognosis Multiple Sclerosis: HALT_MS. 22nd Annual Meeting of the CMSC, Denver, CO, May 28-31, 2007. [Abstract]

Newell KA, Burlingham WJ, Marks WH, Gisler TD, Seyfert VL, Turka LA, Suthanthiran M, Kirk AD. Preliminary Analysis of the ITN Registry of Tolerant Kidney Transplant Recipients. World Transplant Congress, July 22 – 27, 2006, Boston, MA. [Abstract]

Parrish D, McCafferty K. A web-based clinical trials management system: Integration, annotation and deliery of bioinformatics and clinical data within operational workflows of clinical trials. American Medical Informatics Association Spring Congress, Phoenix, AZ, May, 2006. [Poster]

Raddassi K, Bourcier K, Estevam J, Gisler T, Hafler DA, Seyfert-Margolis V. Comparison of two methods CPT and Ficoll to isolate mononuclear cells from peripheral blood. Effect on viability and function of freshly and cryopreserved PBMCs. FOCIS Annual Meeting, San Francisco, CA, June 1-5, 2006. [Abstract]

Sagoo P, Hernandez-Fuentes MP, Flavia R, Jimenez E, Perucha E, Stevenson S, Milton R, Warrens A, Lechler RI. Advances in Immune Monitoring in Renal Transplantation. Poster#1888. World Transplant Congress, Boston, MA, July 2006. Am J Transplant, 2006, (6):s2 p695. [Abstract]

Sagoo P, Hernandez-Fuentes M, Jimenez-Vera E, Rovis F, Hilton R, Warrens A, Lechler RI. Fingerprinting tolerance in Renal Transplantation. Abstract A21. 7th Trends in Immunosuppression, Berlin, February 2006. [Abstract]

Seyfert VL, Asare AL, Bourcier K, Wang R, Gao Z, Casale TB. Transcriptome Seasonal Regulation in Ragweed Allergy. 2007 AAAAI Annual Meeting, San Diego, CA, Feb 23-27, 2007. [Abstract]

Shamji MH, Wilcock LK, Larche M, Francis JN, Durham SR. Validation of a Functional Assay of IgE-Facilitated CD23-Dependent Allergen Binding to B Cells to Monitor Clinical Efficacy of Immunotherapy. 2006 AAAAI Annual Meeting, Miami, FL., March 3-7. Journal of Allergy and Clinical Immunology. Journal of Allergy and Clinical Immunology Vol. 117 (2) S330: 2006. [Abstract]

Stevenson S, Jiang S, Hernandez-Fuentes M, Lombardi G, Barber L, Lechler RI. Efficacy of Indirect pathway antigen processing and allorecognition. Abstract A918. 7th Trends in Immunosuppression, Berlin, February 2006. [Abstract]

Vandenbark AA. Treatment of MS patients with TCR peptide vaccine. 4th International Workshop on T-Cell Vaccination, Galilee, Israel, February 2006.

Vandenbark AA. Treg cells in multiple sclerosis. Nancy Davis MS Center Without Walls Symposium, Los Angeles, CA, November 17, 2006.

Wilcock LK, Francis JN, Paraskavopoulos G, Till SJ, Durham SR. Induction of IL-10 Occurs Early and Precedes Serum IgG Blocking Activity During a Cluster Regimen of Grass Pollen Immunotherapy. 2006 AAAAI Annual Meeting, Miami, FL., March 3-7. Journal of Allergy and Clinical Immunology Vol. 117 (2) S330: 2006. [Abstract]

Wilcock LK, Francis JN, Paraskevopolous G, Aalberse RC, Stapel SO, Till SJ and Durham SR. Increased serum inhibitory activity for basophil histamine release corresponds with reductions in early skin responses in a time-course of grass pollen immunotherapy. British Society of Allergy and Clinical Immunology, Loughborough, July 2006. [Abstract]