Latest News

April 12, 2017

Kidney Graft Function and a B Cell Signature

An article published today in the American Journal of Transplantation examined the prevalence of a previously identified genetic signature associated with tolerance in a cohort of kidney transplant patients who may benefit from immunosuppression minimization. A transplant recipients’ lifetime use of immunosuppressive drugs to prevent rejection exposes them to health complications associated with drug toxicity and long-term immunosuppression.

February 14, 2017

Durable Hay Fever Suppression May Require Three Years of Immunotherapy

Immunotherapy that exposes hay-fever patients to increasing amounts of grass pollen over time can be an effective way to reduce severe allergic symptoms in the long term.

February 2, 2017

HALT-MS Therapy Effective for Inducing Long-Term Sustained Remission of MS Through 5 Years After Transplant

In a study appearing online in Neurology, the HALT-MS trial demonstrated that patients with active relapsing-remitting multiple sclerosis (RRMS) showed sustained remission out to 5 years following high dose immunosuppressive therapy combined with autologous hematopoietic cell transplantation (HDIT/HCT).HALT-MS is a phase II clinical trial of HDIT/HCT for patients with RRMS who experienced relapses with loss of neurological function while on MS disease modifying therapy (DMT).

January 27, 2017

Dr. Jerry Nepom receives 2017 George Eisenbarth Award

We are pleased to announce that Dr. Jerry Nepom, Director of the ITN, has received the 2017 George Eisenbarth Award, a prestigious honor in recognition of his career in research for type 1 diabetes (T1D). The award was presented to Dr. Nepom at the international Immunology of Diabetes conference, held in San Francisco in January. The award was established in 2013 upon the death of George Eisenbarth, a pioneer in the field of type 1 diabetes. Dr. Marion Rewers, from the Barbara Davis Center for Childhood Diabetes, presented this award to Dr.

January 5, 2017

New Peanut Allergy Prevention Guidelines Released Based on ITN's LEAP Study Results

An expert panel sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, issued clinical guidelines to aid health care providers in early introduction of peanut-containing foods to infants to prevent the development of peanut allergy.Peanut allergy is a growing health problem for which no treatment or cure exists.

November 18, 2016

New Publication: Partial Exhaustion of CD8 T Cells in Responders to Anti-CD3 Treatment in New-Onset Type 1 Diabetes

Study results suggesting that T cell exhaustion markers may be correlated with treatment response in type 1 diabetes (T1D) patients from the Immune Tolerance Network’s AbATE study were published today in Science Immunology. This research, led by Alice Long, PhD, and Peter Linsley, PhD, at Benaroya Research Institute, used integrated systems biology and flow cytometry approaches to investigate pathways associated with C-peptide stabilization in responders to anti-CD3 treatment.

August 3, 2016

Abatacept in Relapsing-Remitting Multiple Sclerosis

Abatacept (Orencia®; Bristol-Myers Squibb) did not reduce the number of new gadolinium-enhancing Magnetic Resonance Imaging (MRI) lesions in patients with relapsing-remitting multiple sclerosis compared to a placebo after 24 weeks.

July 7, 2016

ITN Opens ALLTOL Study for Organ Transplant Recipients

The Immune Tolerance Network (ITN) opened up a new observational transplant trial, ALLTOL, with the enrollment of its first two participants at the University of California, San Francisco (UCSF) June 30, 2016. ALLTOL is a prospective cohort study to enroll “operationally tolerant” kidney and liver transplant recipients who have successfully discontinued immunosuppressive medications and continue to have normal function in their transplanted organ.

June 23, 2016

Five Year Follow-up of WISP-R Pediatric Liver Transplant Recipients

The 12 young liver transplant recipients in the Immune Tolerance Network’s WISP-R Study (Withdrawal of Immunosuppression in Pediatric Liver Transplant Recipients) show no immunological or histological signs of rejection four years after coming off all immunosuppressive medications. The data were published last week in Hepatology.WISP-R is a multi-center, single arm pilot study that assessed immunosuppression withdrawal in stable pediatric liver transplant recipients with a parental living donor.

June 20, 2016

Reduced Hypoglycemic Events and Improved Glycemic Variability is Associated with C-peptide Preservation in New-Onset Type 1 Diabetes Patients in the T1DAL Study

Better blood glucose control is correlated with C-peptide preservation, a marker of natural insulin production, in individuals with type 1 diabetes who participated in the Immune Tolerance Network’s T1DAL Study [Inducing Remission in New Onset T1DM with Alefacept (Amevive®)]. This secondary analysis of T1DAL data is the first to demonstrate the correlation between insulin preservation and glycemic control in a clinical trial with an immune-targeting drug in type 1 diabetes.