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In a study published on April 22, 2020 in JACI, data from ITN’s CATEEC clinical trial was used to investigate the connection between asthma and allergic disease and the novel coronavirus, SARS-

The first patient first visit (FPFV) has occurred for ITN’s REBOOT clinical trial. REBOOT is a clinical study that aims to evaluate the safety and effectiveness of belimumab and intravenous rituximab at inducing remission of primary membranous nephropathy (MN) compared to rituximab alone.

The Immune Tolerance Network (ITN) has opened the BEAT-MS clinical trial for enrollment. BEAT-MS or “Best Available Therapy vs. Autologous Hematopoietic Stem Cell Transplant (AHSCT) for MS” will investigate high dose immunosuppression followed by AHSCT – a type of transplant using a patient’s own immune stem cells – compared to the best medical treatment currently available for multiple sclerosis (MS) in participants with relapsing MS.

This week in the article “How to Prevent Food Allergies,” Scientific American discusses the changes over the years to medical advice regarding children and dietary allergens. The article notes the results of the Immune Tolerance Network’s (ITN’s) LEAP (Learning Early About Peanut Allergy) Study that prompted the change in the American Academy of Pediatrics (AAP) guidance.

A follow-up analysis of the participants from ITN’s LEAP (Learning Early About Peanut Allergy) Study has identified a strong association between the development of peanut allergy and the MALT1 gene. These findings were recently published in the February 27th issue of the Journal of Allergy and Clinical Immunology.

ITN’s ACTIVATE (Vaginal Microbiome Exposure and Immune Responses in C-section Infants) has opened for recruitment. The goal of this pilot study is to investigate how differences in the microbiome of a baby may protect, or put them at risk, for allergies.

The Immune Tolerance Network (ITN) is currently developing a clinical trial to test a new treatment for vitiligo, an autoimmune disease in which the immune system attacks pigment containing cells in the skin leading to disfiguring white spots.

The ITN is currently seeking proposals for clinical trials for novel therapeutic approaches to induce B cell tolerance in patients who are donor-sensitized and/or to prevent sensitization.

The gold standard to diagnose food allergy is an oral food challenge (OFC), but it can cause severe allergic reactions in some individuals. Reliable in vitro tests would eliminate undesirable aspects of OFCs, allowing easier and safer diagnoses and assessments of clinical responses to treatments.