ITN Allergy Mechanistic Data at AAAAI Annual Meeting

February 28, 2012

Data from Immune Tolerance Network (ITN) mechanistic work will be reported at the upcoming American Academy of Allergy, Asthma, and Immunology (AAAAI) meeting on March 2-6 in Orlando, FL.

Two abstracts present data from an ITN pilot study conducted to help design the mechanistic strategy for a larger trial comparing SLIT vs. SCIT immunotherapy in allergic rhinitis:  

Interluekin-35 suppresses allergen-specific Th2 response in patients with grass pollen induced seasonal allergic rhinitis (Mohamed Shamji, PhD, Imperial College London)

Effects of nasal allergen challenge on T cell signature in peripheral blood in patients with severe seasonal allergic rhinitis (Mohamed Shamji, PhD, Imperial College London)

A third abstract evaluates the diagnostic value of a functional assay for detecting peanut allergy vs. asymptomatic peanut IgE-sensitivity:

IgE-facilitated peanut-allergen binding to B cells (IgE-FAB peanut): a diagnostic biomarker for peanut allergy? (Mohamed Shamji, PhD, Imperial College London)

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