April 2, 2021
An investigation of the allergen-specific immunoglobulin responses following sublingual (SLIT) and subcutaneous (SCIT) immunotherapy for timothy grass pollen allergy in was published today in the Journal of Allergy and Clinical Immunology today.
Using samples from ITN's GRASS Study (Gauging Response in Allergic Rhinitis to Sublingual and Subcutaneous Immunotherapy), the authors report for the first time the difference in allergen-specific IgA responses to SLIT compared to SCIT.
While initial reports from the GRASS Study focused on clinical response and changes in IgE levels, this article reports on a detailed examination of the effect of SCIT and SLIT on a wider spectrum of humoral responses, such as nasal and systemic IgA1, IgA2, IgG, and IgG4. Assessing the effect of allergen immunotherapy on IgA is
We report an induction of IgA1 and IgA2 after SLIT and IgG4 after SCIT. These results suggest that there are key differences in the mechanisms of action between SLIT and SCIT.
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