Sandy Feng, MD, PhD (University of California, San Francisco) will present 5-year follow-up data on tolerant patients from the Immune Tolerance Network’s (ITN’s) WISP-R study, “Withdrawal of Immunosuppression in Pediatric Liver Transplant Recipients” next week at the annual American Transplant Congress (ATC) meeting in Seattle, WA. The talk will report on donor-specific antibody (DSA) in relation to 5-year outcomes. The primary results from the WISP-R study were reported last year in The Journal of the American Medical Association.
An abstract from Tatsuo Kawai, MD, PhD, (Massachusetts General Hospital) et al. will present 10-year follow-up data on tolerant patients who received a combined kidney and bone marrow transplant in the ITN’s Mixed Chimerism study, “Renal Allograft Tolerance Through Mixed Chimerism.” These outcomes were recently discussed in a letter in the New England Journal of Medicine.
Using samples from a tolerant patient in the Mixed Chimerism study, another abstract from Heather Morris, MD, (Columbia University) et al. will present data on a new T cell repertoire deep sequencing approach to identify and track donor-reactive T cell clones before and after transplantation.
More information about ATC meeting abstracts can be found here.