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Latest News

April 29, 2020

Allergy, Asthma and COVID-19 Susceptibility

In a study published on April 22, 2020 in JACI, data from ITN’s CATEEC clinical trial was used to investigate the connection between asthma and allergic disease and the novel coronavirus, SARS-

> read more
March 10, 2020

ITN’s CATEEC Article Selected as Editor’s Choice Feature by JACI

The ITN article that reported the results of the CATEEC clinical trial, which compared clinical and biological responses to cat allergen exposure by nasal allergen challenge (NAC) or environmental exposure chamber (EEC) was selected to be an Editors’ Choice feature and was displayed on the American Academy of Allergy Asthma & Immunology (AAAAI) website.

> read more
March 06, 2020

ITN’s REBOOT Study for Primary Membranous Nephropathy Has First Patient Visit

The first patient first visit (FPFV) has occurred for ITN’s REBOOT clinical trial. REBOOT is a clinical study that aims to evaluate the safety and effectiveness of belimumab and intravenous rituximab at inducing remission of primary membranous nephropathy (MN) compared to rituximab alone.

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January 06, 2020

BEAT-MS, a Clinical Trial of Autologous Hematopoietic Stem Cell Transplantation versus Best Available Therapy for Multiple Sclerosis, Begins Enrollment

The Immune Tolerance Network (ITN) has opened the BEAT-MS clinical trial for enrollment. BEAT-MS or “Best Available Therapy vs. Autologous Hematopoietic Stem Cell Transplant (AHSCT) for MS” will investigate high dose immunosuppression followed by AHSCT – a type of transplant using a patient’s own immune stem cells – compared to the best medical treatment currently available for multiple sclerosis (MS) in participants with relapsing MS.

> read more
July 30, 2019

ITN’s LEAP Study Continues to Influence Dietary Guidance for Infants as well as Product Development

This week in the article “How to Prevent Food Allergies,” Scientific American discusses the changes over the years to medical advice regarding children and dietary allergens. The article notes the results of the Immune Tolerance Network’s (ITN’s) LEAP (Learning Early About Peanut Allergy) Study that prompted the change in the American Academy of Pediatrics (AAP) guidance.

> read more
March 08, 2019

A Strong Association Between MALT1 Locus and Peanut Allergy

A follow-up analysis of the participants from ITN’s LEAP (Learning Early About Peanut Allergy) Study has identified a strong association between the development of peanut allergy and the MALT1 gene. These findings were recently published in the February 27th issue of the Journal of Allergy and Clinical Immunology.

> read more
December 14, 2018

ACTIVATE Study Investigating Microbiome Exposure in C-section Infants and Allergy Development Begins Recruitment

ITN’s ACTIVATE (Vaginal Microbiome Exposure and Immune Responses in C-section Infants) has opened for recruitment. The goal of this pilot study is to investigate how differences in the microbiome of a baby may protect, or put them at risk, for allergies.

> read more
July 23, 2018

ITN Vitiligo Clinical Trial in the News

The Immune Tolerance Network (ITN) is currently developing a clinical trial to test a new treatment for vitiligo, an autoimmune disease in which the immune system attacks pigment containing cells in the skin leading to disfiguring white spots.

> read more
June 27, 2018

Seeking Proposals for Clinical Trials of Desensitization in Solid Organ Transplantation

The ITN is currently seeking proposals for clinical trials for novel therapeutic approaches to induce B cell tolerance in patients who are donor-sensitized and/or to prevent sensitization.

> read more
June 01, 2018

GRASS Mechanistic Manuscript Highlighted as JACI Editors’ Choice

ITN’s recently published article, reporting the mechanistic results from the GRASS clinical trial, was highlighted in The Journal of Allergy and Clinical Immunology’s Editors’ Choice Feature in its May 2018 issue.

> read more

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The Immune Tolerance Network and is sponsored by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

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