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Latest News

January 30, 2015

ITN Opens the EXTEND Study in Type 1 Diabetes

A new ITN type 1 diabetes trial opened today at the first site, Sanford Health in Sioux Falls, SD.

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January 27, 2015

Request for Proposals: ITN Seeks Antigen-Specific T Cell Tolerance Assays for Myelin-Associated Antigens in Multiple Sclerosis

The ITN has an interest in antigen-specific T cell tolerance in multiple sclerosis, an autoimmune disease in which autoreactive T cells specific for myelin-associated antigens are thought to play a role in pathogenesis. Assessment of antigen-specific tolerance in multiple sclerosis will require reliable assays to detect and phenotype T cell responses to myelin-associated antigens in a clinical trial setting. To this end, the ITN is seeking assays for assessing functional tolerance and biomarkers of tolerance in antigen-specific CD4 and CD8 effector and regulatory T cells.

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January 21, 2015

Immunotherapy Research in Seattle and the ITN

An article in Seattle Magazine about the landscape for immunotherapy in Seattle gives a nice mention of the Benaroya Research Institute and the Immune Tolerance Network:

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January 05, 2015

Stem Cell Transplants May Halt Progression of Multiple Sclerosis

Washington, DC - Three-year outcomes from an ongoing clinical trial suggest that high-dose immunosuppressive therapy followed by transplantation of a person's own blood-forming stem cells may induce sustained remission in some people with relapsing-remitting multiple sclerosis (RRMS). RRMS is the most common form of MS, a progressive autoimmune disease in which the immune system attacks the brain and spinal cord.

> read more
November 03, 2014

CALIBRATE Trial for Lupus Nephritis Opens

Last Friday the Immune Tolerance Network (ITN) opened a new combination therapy study in lupus nephritis, CALIBRATE, at University of California, San Francisco (UCSF). The CALIBRATE Study will be led by Drs. Betty Diamond (North Shore Feinstein Institute), David Wofsy (UCSF), Cynthia Aranow (North Shore Feinstein Institute), and Maria Dall’Era (UCSF), and will test a novel regimen of rituximab (Rituxan, Genentech, Inc.) followed by belimumab (BENLYSTA®, GlaxoSmithKline) in patients with refractory lupus nephritis.

> read more
October 29, 2014

Abatacept for Lupus Nephritis (the ACCESS Study)

The results of the ACCESS study, “Abatacept and Cyclophosphamide Combination Therapy for Lupus Nephritis” sponsored by the Immune Tolerance Network (ITN) and led by Drs.

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October 22, 2014

ITN Will Receive National Academies' Award For TrialShare On October 23rd

The Immune Tolerance Network (ITN) will receive the National Academies' Board on Research Data and Information Challenge Award for 

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October 09, 2014

ITN Launches the CATNIP Cat Allergy Immunotherapy Study

On Wednesday, October 8th the ITN opened the CATNIP study, “Anti-TSLP plus antigen-specific immunotherapy for induction of tolerance in individuals with cat allergy,” at the first site, the University of Wisconsin.  CATNIP will test whether a novel therapeutic approach, cat immunotherapy combined with an investigational new drug called MEDI9929/AMG 157 (an anti-TSLP antibody being co-developed by Amgen and Medimmune) can lead to lasting tolerance to cat allergen.

> read more
July 28, 2014

New White Paper - Tolerance: One Transplant for Life

A White Paper published yesterday in Transplantation (co-authored by ITN Deputy Director Larry Turka, MD) outlines recommendations from an international workshop convened by The Transplantation Society (TTS) to determine the necessary steps to make tolerance protocols a standard of care for transplant over the next decade.  To date three academic centers have employed successful tolerance-inducing protocols in kidney transplant recipients (Stanf

> read more
July 16, 2014

Immune Tolerance Network’s (ITN) TrialShare Wins National Academies Board on Research Data and Information Challenge

The Immune Tolerance Network’s (ITN) TrialShare Clinical Trials Research Portal (www.ITNTrialShare.org) has won the National Academy of Sciences Data and Information Challenge. The theme of this year’s competition, launched and judged by the academy’s Board on Research Data and Information (BDRI), was “Using Data for the Public Good.”

> read more

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The Immune Tolerance Network and is sponsored by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

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