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Latest News

October 24, 2013

Data from ITN Lupus Nephritis Study to be presented at Upcoming Rheumatology and Nephrology Conferences

Clinical data from the ITN’s ACCESS study (Abatacept and Cyclophosphamide Combination Therapy for Lupus Nephritis) will be presented at two upcoming conferences. The ACCESS study examined whether the combination of abatacept (CTLA4-Ig) and cyclophosphamide is able to better induce tolerance compared to the Euro-Lupus regimen (low-dose pulse cyclophosphamide).

> read more
October 04, 2013

ITN TrialShare Absorbs BioShare

The Immune Tolerance Network (ITN) is retiring ITN BioShare. ITN’s inventory of clinical trial biospecimens is now available through ITN TrialShare. Now that ITN’s biorepository is accessible through TrialShare, all web traffic to BioShare will redirect to www.ITNTrialShare.org.

> read more
September 23, 2013

New Publication: Results from the T1DAL Type 1 Diabetes Study

Encouraging results from the T1DAL study (Targeting effector memory T cells with alefacept in new onset type 1 diabetes), led by Dr. Mark Rigby (Indiana University) are published today in The Lancet Diabetes & Endocrinology.

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September 10, 2013

ITN Mourns the Passing of Lloyd Mayer

It is with great sadness that we report the passing of Lloyd Mayer, MD.

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August 28, 2013

New Publication: START Type 1 Diabetes Study Showed No Difference in Insulin Production Decline

Results from the START clinical study (Study of Thymoglobulin to Arrest Newly Diagnosed Type 1 Diabetes), led by Dr. Steve Gitelman (University of California, San Francisco) with the Immune Tolerance Network (ITN), were published in an article today in The Lancet Diabetes & Endocrinology. The study enrolled 58 new-onset type 1 diabetic subjects ages 12-35.

> read more
August 07, 2013

ITN TrialShare Sees Public Usage Rise Following Publication of the First Manuscript with Embedded Links to the System

In an article reporting the 18-month results of the Immune Tolerance Network’s (ITN) RAVE clinical trial, published August 1st in the New England Journal of Medicine, the ITN is providing unfettered access to the underlying clinical data and analysis code via the new clinical trials research portal, ITN TrialShare (itntrialshare.org).

> read more
August 01, 2013

ITN Achieves Scientific Manuscript First - Provides Open, Interactive Access to Clinical Trial Data with New Publication: Rituximab Therapy Effective for ANCA-associated Vasculitis

In an article reporting the 18-month results of the Immune Tolerance Network’s (ITN) RAVE clinical trial, published August 1st in the New England Journal of Medicine, the ITN is providing unfettered access to the underlying clinical data and analysis code via the new clinical trials research portal, ITN TrialShare

> read more
July 24, 2013

IMPACT Study Launches Today: Peanut Oral Immunotherapy in Young Children

The Immune Tolerance Network’s (ITN’s) IMPACT Study, “Oral Immunotherapy for Induction of Tolerance and Desensitization in Peanut-Allergic Children,” opened for enrollment today. This will be the first major study to examine whether oral immunotherapy can lead to durable, lasting tolerance to peanut among young peanut-allergic children. This study will be led by ITN investigator Wesley Burks, MD, Chair of the Department of Pediatrics at UNC Chapel Hill.

> read more
July 08, 2013

New Publication: AbATE Type 1 Diabetes Study Reveals Subset of Patients with Strong Response to Therapy

Primary results from the Immune Tolerance Network’s AbATE study (Autoimmunity-Blocking Antibody for Tolerance in Recently Diagnosed Type 1 Diabetes) were published online today in Diabetes. The Phase II AbATE study, led by Kevan Herold, MD (Yale University), tested two doses of anti-CD3 given one year apart in new onset type 1 diabetics compared to control.

> read more
June 25, 2013

Prophylactic use of Sublingual Allergen Immunotherapy in High-Risk Children

In a letter published recently in the Journal of Allergy and Clinical Immunology, Immune Tolerance Network (ITN) investigators describe the experience of the ITN’s GPAC study (Immunoprophylaxis of Allergic Disease) that aimed to test whether early intervention with a form of oral immunotherapy in at-risk young children could prevent the development of asthma.

> read more

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The Immune Tolerance Network and is sponsored by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

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