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Latest News

July 24, 2013

IMPACT Study Launches Today: Peanut Oral Immunotherapy in Young Children

The Immune Tolerance Network’s (ITN’s) IMPACT Study, “Oral Immunotherapy for Induction of Tolerance and Desensitization in Peanut-Allergic Children,” opened for enrollment today. This will be the first major study to examine whether oral immunotherapy can lead to durable, lasting tolerance to peanut among young peanut-allergic children. This study will be led by ITN investigator Wesley Burks, MD, Chair of the Department of Pediatrics at UNC Chapel Hill.

> read more
July 08, 2013

New Publication: AbATE Type 1 Diabetes Study Reveals Subset of Patients with Strong Response to Therapy

Primary results from the Immune Tolerance Network’s AbATE study (Autoimmunity-Blocking Antibody for Tolerance in Recently Diagnosed Type 1 Diabetes) were published online today in Diabetes. The Phase II AbATE study, led by Kevan Herold, MD (Yale University), tested two doses of anti-CD3 given one year apart in new onset type 1 diabetics compared to control.

> read more
June 25, 2013

Prophylactic use of Sublingual Allergen Immunotherapy in High-Risk Children

In a letter published recently in the Journal of Allergy and Clinical Immunology, Immune Tolerance Network (ITN) investigators describe the experience of the ITN’s GPAC study (Immunoprophylaxis of Allergic Disease) that aimed to test whether early intervention with a form of oral immunotherapy in at-risk young children could prevent the development of asthma.

> read more
June 18, 2013

ITN Type 1 Diabetes Data to be featured at the American Diabetes Association (ADA) Scientific Sessions

Data from three ITN type 1 diabetes trials will be featured during the “Clinical Trials of T Cell Therapeutics for Reversing Type 1 Diabetes” session at the Annual American Diabetes Association (ADA) Scientific Sessions in Chicago, IL. This session will take place on June 22 from 8:00am-10:00am CT.

> read more
June 14, 2013

New Publication: Clinical Outcomes of Remission Induction Therapy for Severe ANCA-Associated Vasculitis

In a manuscript published this week in Arthritis & Rheumatism, Immune Tolerance Network (ITN) investigators sought to better understand the distinction between patients who did and did not achieve the primary endpoint in the RAVE Study (Rituximab for the Treatment of ANCA-Associated Vasculitis and Microscopic Polyangiitis).

> read more
May 17, 2013

ITN Transplant Data to be Presented at American Transplant Congress (ATC) Meeting in Seattle, WA

Sandy Feng, MD, PhD (University of California, San Francisco) will present 5-year follow-up data on tolerant patients from the Immune Tolerance Network’s (ITN’s) WISP-R study, “Withdrawal of Immunosuppression in Pediatric Liver Transplant Recipients” next week at the annual American Transplant Congress (ATC) meeting in Seattle, WA.

> read more
May 09, 2013

An Update on Tolerant Kidney Transplant Recipients

A letter published today in the New England Journal of Medicine reports on the long-term outcomes of patients from two ITN-sponsored combined kidney and bone marrow transplantation studies led by David H. Sachs, MD (Massachusetts General Hospital), Tatsuo Kawai, MD, PhD (Massachusetts General Hospital), Megan Sykes, MD (Columbia University) and A. Benedict Cosimi, MD (Massachusetts General Hospital).

> read more
May 07, 2013

New Publication: High-throughput Gene Sequencing to Estimate T cell Populations

The quantification of mature T cell subsets is an important prognostic marker for understanding disease. Killer T cells and Helper T cells, characterized by the expression of cell surface marker proteins CD8 or CD4, respectively, effect different aspects of the adaptive immune system, and the ratio of these two populations can reveal important information about the state of the immune system.

> read more
April 18, 2013

RAVE Study Data Presented at 16th International Vasculitis & ANCA Workshop in Paris

Three abstracts from the ITN’s RAVE study (Rituximab for the Treatment of ANCA-Associated Vasculitis and Microscopic Polyangiitis) led by John Stone, MD (Massachusetts General Hospital) and Ulrich Specks, MD (Mayo Clinic) were presented this week by the RAVE team at the 16th International Vasculitis & ANCA Workshop in Paris, France. These abstracts include:

> read more
April 11, 2013

ITN’s TrialShare wins Honorable Mention at Bio-IT World Best Practices Awards

Bio-IT World announced the winners of its Best Practices Awards competition yesterday at its annual meeting in Boston, MA. Out of the 34 projects evaluated this year, including those from industry giants GlaxoSmithKline, Amgen and Genentech, the Immune Tolerance Network’s (ITN) Clinical Trials Research Portal, TrialShare, received one of only two honorable mentions (see summary of the awards

> read more

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The Immune Tolerance Network and is sponsored by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

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