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  • Allergy & Asthma
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  • Clinical Trial Info

Grass Pollen Immunotherapy Plus Dupilumab For Tolerance Induction (GRADUATE)

Vaginal Microbiome Exposure and Immune Responses in C-section Infants (ACTIVATE)

Vaginal Microbiome Exposure and Immune Responses in C-section Infants (ACTIVATE)

Follow up of LEAP Participants and Their Families (LEAP Trio)

Immune Tolerance in Allergy & Asthma

Allergen immunotherapy, which helps reduce sensitization by giving gradually increasing doses of an allergen, can improve symptoms for many people but the effects are often not permanent. The Immune Tolerance Network (ITN) is focused on achieving long-lasting tolerance to allergens by investigating treatment approaches that improve on current immunotherapy methods, such as combining immunotherapy with other agents to enhance responses, or exploring new allergen preparations and routes of administration to maximize effectiveness.

This page contains a list of ITN's allergy and asthma clinical trials that are currently enrolling participants. To see all of ITN's active and completed studies in allergy and asthma, please visit For Researchers.

Clinical Trials - Allergy & Asthma

Active

Grass Pollen Immunotherapy Plus Dupilumab For Tolerance Induction (GRADUATE)

Principal Investigator:
Stephen R. Durham, MD, Imperial College, London
GRADUATE is a clinical research trial, which will test whether a novel drug called Dupixent® given with grass pollen immunotherapy will help the immunotherapy work in a shorter treatment period and remain effective after the completion of treatment.
Learn more: Study Summary Clinicaltrials.gov Study Website

Vaginal Microbiome Exposure and Immune Responses in C-section Infants (ACTIVATE)

Principal Investigator:
Hugh Sampson, MD , Icahn School of Medicine at Mount Sinai , New York
Jose Clemente, PhD , Icahn Institute for Genomics and Multiscale Biology , New York
ACTIVATE is a clinical trial investigating the impact of the infant microbiome on allergy development.
Learn more: Study Summary Clinicaltrials.gov Study Website

Follow up of LEAP Participants and Their Families (LEAP Trio)

Principal Investigator:
Gideon Lack, Evelina Childrens Hospital, London, UK
LEAP Trio is a follow-up to the LEAP study of early peanut consumption. LEAP Trio will investigate the durability of tolerance to peanut allergen in LEAP participants at age 12, development of peanut allergy in younger siblings of LEAP participants, and parental characteristics that may impact development of food allergy.
Learn more: Study Summary Clinicaltrials.gov Study Website
View All Clinical Trials

The Immune Tolerance Network and is sponsored by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

National Institute of Allergy and Infectious Diseases

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