Publications
Articles
Use of HLA class II tetramers in tracking antigen-specific T cells and mapping T-cell epitopes
(2003). Methods, 29 (3), 282-288. , PMID: 12725793
Reijonen H, Kwok WW
[Reprint] [PubMed]
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Reijonen H, Kwok WW (2003). Use of HLA class II tetramers in tracking antigen-specific T cells and mapping T-cell epitopes. Methods, 29 (3), 282-288.
ICA512(IA-2) Epitope specific assays distinguish transient from diabetes associated autoantibodies
(2002). J Autoimmun, 18 (2), 191-196. , PMID: 11908951
Miao D, Yu L, Tiberti C, Cuthbertson DD, Rewers M, di Mario U, Eisenbarth GS, Dotta F
[Reprint] [PubMed]
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Miao D, Yu L, Tiberti C, Cuthbertson DD, Rewers M, di Mario U, Eisenbarth GS, Dotta F (2002). ICA512(IA-2) Epitope specific assays distinguish transient from diabetes associated autoantibodies. J Autoimmun, 18 (2), 191-196.
Evolution of the Enzyme-Linked Immunosorbent Spot Assay for post-transplant alloreactivity as a potentially useful immune monitoring tool
(2002). Am J Transplant, 2 (9), 857-866. , PMID: 12392292
Gebauer BS, Hricik DE, Atallah A, Bryan K, Riley J, Tary-Lehmann M, Greenspan NS, Dejelo C, Boehm BO, Hering BJ, Heeger PS
[Reprint] [PubMed]
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Gebauer BS, Hricik DE, Atallah A, Bryan K, Riley J, Tary-Lehmann M, Greenspan NS, Dejelo C, Boehm BO, Hering BJ, Heeger PS (2002). Evolution of the Enzyme-Linked Immunosorbent Spot Assay for post-transplant alloreactivity as a potentially useful immune monitoring tool. Am J Transplant, 2 (9), 857-866.
Noninvasive diagnosis of BK virus nephritis by measurement of messenger RNA for BK virus VP1 in urine
(2002). Transplantation, 74 (7), 987-994. , PMID: 12394843
Ding R, Medeiros M, Dadhania D, Muthukumar T, Kracker D, Kong JM, Epstein SR, Sharma VK, Seshan SV, Li B, Suthanthiran M
[Reprint] [PubMed]
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Ding R, Medeiros M, Dadhania D, Muthukumar T, Kracker D, Kong JM, Epstein SR, Sharma VK, Seshan SV, Li B, Suthanthiran M (2002). Noninvasive diagnosis of BK virus nephritis by measurement of messenger RNA for BK virus VP1 in urine. Transplantation, 74 (7), 987-994.
Monitoring the patient off immunosuppression: Conceptual framework for a proposed tolerance assay study in liver transplant recipients
(2001). Transplantation, 72 (8), S13-S22. , PMID: 11888150
Thomson AW, Mazariegos GV, Reyes J, Donnenberg VS, Donnenberg AD, Bentlejewski C, Zahorchak AF, O'Connell PJ, Fung JJ, Jankowska-Gan E, Burlingham WJ, Heeger PS, Zeevi A
[Reprint] [PubMed]
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Thomson AW, Mazariegos GV, Reyes J, Donnenberg VS, Donnenberg AD, Bentlejewski C, Zahorchak AF, O'Connell PJ, Fung JJ, Jankowska-Gan E, Burlingham WJ, Heeger PS, Zeevi A (2001). Monitoring the patient off immunosuppression: Conceptual framework for a proposed tolerance assay study in liver transplant recipients. Transplantation, 72 (8), S13-S22.
The Immune Tolerance Network: The "Holy Grail" comes to the clinic
(2000). J Am Soc Nephrol, 11 (11), 2141-2146. , PMID: 11053493
Bluestone JA, Matthews JB, Krensky AM
[Reprint] [PubMed]
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Bluestone JA, Matthews JB, Krensky AM (2000). The Immune Tolerance Network: The "Holy Grail" comes to the clinic. J Am Soc Nephrol, 11 (11), 2141-2146.
Review & Commentary
Recent progress in the genetic and epigenetic underpinnings of atopy
(2023). Journal of Allergy and Clinical Immunology, 151 (1), 60-69. http://dx.doi.org/10.1016/j.jaci.2022.10.027, PMID: 36608983
Baloh C, Mathias R
[PubMed]
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Baloh C, Mathias R (2023). Recent progress in the genetic and epigenetic underpinnings of atopy. Journal of Allergy and Clinical Immunology, 151 (1), 60-69.
Incorporating genetics in identifying peanut allergy risk and tailoring allergen immunotherapy: A perspective on the genetic findings from the LEAP trial
(2023). Journal of Allergy and Clinical Immunology, Epub ahead of print. http://dx.doi.org/10.1016/j.jaci.2022.12.819
Huffaker, M. F., Kanchan, K., Bahnson, H. T., Baloh, C., Lack, G., Nepom, G. T., & Mathias, R. A
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Huffaker, M. F., Kanchan, K., Bahnson, H. T., Baloh, C., Lack, G., Nepom, G. T., & Mathias, R. A (2023). Incorporating genetics in identifying peanut allergy risk and tailoring allergen immunotherapy: A perspective on the genetic findings from the LEAP trial. Journal of Allergy and Clinical Immunology, Epub ahead of print.
Chimerism-Based Tolerance to Kidney Allografts in Humans: Novel Insights and Future Perspectives
(2022). Front Immunol, 12 (791725). http://dx.doi.org/10.3389/fimmu.2021.791725, PMID: 35069574, PMCID: PMC8767096
Podestà MA, Sykes M.
[Reprint] [PubMed]
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Podestà MA, Sykes M. (2022). Chimerism-Based Tolerance to Kidney Allografts in Humans: Novel Insights and Future Perspectives. Front Immunol, 12 (791725).
Biomarkers and mechanisms of tolerance induction in food allergic patients drive new therapeutic approaches
(2022). Front Immunol, 13. http://dx.doi.org/10.3389/fimmu.2022.972103, PMID: 36263023, PMCID: PMC9574092
Baloh CH, Huffaker MF and Laidlaw T.
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Baloh CH, Huffaker MF and Laidlaw T. (2022). Biomarkers and mechanisms of tolerance induction in food allergic patients drive new therapeutic approaches. Front Immunol, 13.
Synergistic targeting of immunologic pathways to empower durable tolerance therapies
(2022). Front Immunol, 13 (962177). http://dx.doi.org/10.3389/fimmu.2022.962177, PMID: 36119087, PMCID: PMC9478166
Nepom, GT
[Reprint] [PubMed]
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Nepom, GT (2022). Synergistic targeting of immunologic pathways to empower durable tolerance therapies. Front Immunol, 13 (962177).
Reply to: Life-threatening anaphylaxis to peanut — impossible to predict?
(2022). Journal of Allergy and Clinical Immunology, 149 (3), 1129-1131. http://dx.doi.org/10.1016/j.jaci.2021.12.766, PMID: 35000772
Santos, A. F., Evans, E., O'Rourke, C., Bahnson, H. T., Lack, G.
[Reprint] [PubMed]
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Santos, A. F., Evans, E., O'Rourke, C., Bahnson, H. T., Lack, G. (2022). Reply to: Life-threatening anaphylaxis to peanut — impossible to predict?. Journal of Allergy and Clinical Immunology, 149 (3), 1129-1131.
The Prevention of Milk Allergy and the Risks of Stopping Too Soon
(2022). J Allergy Clin Immunol Pract, 10 (1), 180-181. http://dx.doi.org/10.1016/j.jaip.2021.09.011, PMID: 35000732
Huffaker M
[Reprint] [PubMed]
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Huffaker M (2022). The Prevention of Milk Allergy and the Risks of Stopping Too Soon. J Allergy Clin Immunol Pract, 10 (1), 180-181.
Allergen immunotherapy: past, present and future
(2022). Nat Rev Immunol, Epub ahead of print, 1-12. http://dx.doi.org/10.1038/s41577-022-00786-1, PMID: 36253555, PMCID: PMC9575636
Durham SR, Shamji MH.
[Reprint] [PubMed]
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Durham SR, Shamji MH. (2022). Allergen immunotherapy: past, present and future. Nat Rev Immunol, Epub ahead of print, 1-12.
Uncovering Pathways to Personalized Therapies in Type 1 Diabetes
(2021). Diabetes, 7 (4), 831-841. http://dx.doi.org/10.2337/db20-1185, PMID: 33741606, PMCID: PMC7980192
Linsley PS, Greenbaum CJ, GT Nepom
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Linsley PS, Greenbaum CJ, GT Nepom (2021). Uncovering Pathways to Personalized Therapies in Type 1 Diabetes. Diabetes, 7 (4), 831-841.
Approaches to Establishing Tolerance in Immune Mediated Diseases
(2021). Front Immunol, 12, 744804. http://dx.doi.org/10.3389/fimmu.2021.744804
Huffaker M F, Sanda S, Chung S, St. Clair EW, Nepom GT, Smilek DE
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Huffaker M F, Sanda S, Chung S, St. Clair EW, Nepom GT, Smilek DE (2021). Approaches to Establishing Tolerance in Immune Mediated Diseases. Front Immunol, 12, 744804.
Overview of oral tolerance induction for prevention of food allergy—Where are we now?
(2021). Allergy, 76 (9), 2684-2698. http://dx.doi.org/10.1111/all.14758, PMID: 33539570
Krawiec M, Fisher HR, Du Toit G, Bahnson HT, Lack G.
[PubMed]
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Krawiec M, Fisher HR, Du Toit G, Bahnson HT, Lack G. (2021). Overview of oral tolerance induction for prevention of food allergy—Where are we now?. Allergy, 76 (9), 2684-2698.
Food allergy
(2018). Nat Rev Dis Primers, 4 (4), 17098. http://dx.doi.org/10.1038/nrdp.2017.98, PMID: 29300005
Renz H, Allen KJ, Sicherer SH, Sampson HA, Lack G, Beyer K, Oettgen HC
[Reprint] [PubMed]
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Renz H, Allen KJ, Sicherer SH, Sampson HA, Lack G, Beyer K, Oettgen HC (2018). Food allergy. Nat Rev Dis Primers, 4 (4), 17098.
Biomarkers of operational tolerance following kidney transplantation - The immune tolerance network studies of spontaneously tolerant kidney transplant recipients.
(2018). Hum Immunol., 79 (5), 380-387. http://dx.doi.org/10.1016/j.humimm.2018.02.007, PMID: 29448053, PMCID: PMC5924709
Newell KA, Turka LA, Adams AB
[Reprint] [PubMed]
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Newell KA, Turka LA, Adams AB (2018). Biomarkers of operational tolerance following kidney transplantation - The immune tolerance network studies of spontaneously tolerant kidney transplant recipients.. Hum Immunol., 79 (5), 380-387.
Treatment for food allergy
(2018). J Allergy Clin Immunol, 141 (1), 1-9. http://dx.doi.org/10.1016/j.jaci.2017.11.004, PMID: 29307409
Burks AW, Sampson HA, Plaut M, Lack G, Akdis C
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Burks AW, Sampson HA, Plaut M, Lack G, Akdis C (2018). Treatment for food allergy. J Allergy Clin Immunol, 141 (1), 1-9.
Mechanisms of food allergy
(2018). J Allergy Clin Immunol, 141 (1), 11-19. http://dx.doi.org/10.1016/j.jaci.2017.11.005, PMID: 29307410
Sampson HA, O'Mahony, L. Burks, AW. Plaut, M. Lack, Akdis CA
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Sampson HA, O'Mahony, L. Burks, AW. Plaut, M. Lack, Akdis CA (2018). Mechanisms of food allergy. J Allergy Clin Immunol, 141 (1), 11-19.
Immune monitoring of transplant patients in transient mixed chimerism tolerance trials
(2018). Hum Immunol, 79 (5), 334-342. http://dx.doi.org/10.1016/j.humimm.2017.12.011, PMID: 29289741, PMCID: PMC5924718
Sykes M
[Reprint] [PubMed]
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Sykes M (2018). Immune monitoring of transplant patients in transient mixed chimerism tolerance trials. Hum Immunol, 79 (5), 334-342.
The challenges of preventing food allergy: Lessons learned from LEAP and EAT
(2018). Ann Allergy Asthma Immunol, 121 (3), 313-319. http://dx.doi.org/10.1016/j.anai.2018.06.008, PMID: 29909054
Fisher HR, Du Toit G, Bahnson HT, Lack G
[Reprint] [PubMed]
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Fisher HR, Du Toit G, Bahnson HT, Lack G (2018). The challenges of preventing food allergy: Lessons learned from LEAP and EAT. Ann Allergy Asthma Immunol, 121 (3), 313-319.
Basophil Activation Test: Old and New Applications in Allergy
(2018). Current Allergy and Asthma Reports, 18 (77). http://dx.doi.org/10.1007/s11882-018-0831-5, PMID: 30430289
Hemmings O, Kwok M, McKendry R, Santos AF
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Hemmings O, Kwok M, McKendry R, Santos AF (2018). Basophil Activation Test: Old and New Applications in Allergy. Current Allergy and Asthma Reports, 18 (77).
Food Allergy: Unmet Needs and New Perspectives
(2017). J Allergy Clin Immunol Pract, 5 (2), 295. http://dx.doi.org/10.1016/j.jaip.2017.01.002, PMID: 28283155
Wang J, Lack G
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Wang J, Lack G (2017). Food Allergy: Unmet Needs and New Perspectives. J Allergy Clin Immunol Pract, 5 (2), 295.
Statistical Considerations of Food Allergy Prevention Studies
(2017). J Allergy Clin Immunol Pract, 5 (2), 274-82. http://dx.doi.org/10.1016/j.jaip.2016.12.007, PMID: 28283152
Bahnson HT, Du Toit G, Lack G
[Reprint] [PubMed]
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Bahnson HT, Du Toit G, Lack G (2017). Statistical Considerations of Food Allergy Prevention Studies. J Allergy Clin Immunol Pract, 5 (2), 274-82.
Academic, Foundation, and Industry Collaboration in Finding New Therapies
(2017). N Engl J Med, 376 (18), 1762-9. http://dx.doi.org/10.1056/NEJMra1612575, PMID: 28467868
Nepom GT, Ramsey BW, Lonial S
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Nepom GT, Ramsey BW, Lonial S (2017). Academic, Foundation, and Industry Collaboration in Finding New Therapies. N Engl J Med, 376 (18), 1762-9.
Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy
(2017). Immunol Rev, 276 (1), 192-212. http://dx.doi.org/10.1111/imr.12523, PMID: 28258702, PMCID: PMC5338458
Kean LS, Turka LA, Blazar BR
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Kean LS, Turka LA, Blazar BR (2017). Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy. Immunol Rev, 276 (1), 192-212.
Letter of response to Greenhawt et al. 'LEAPing Through the Looking Glass: Secondary Analysis of the Effect of Skin Test Size and Age of Introduction on Peanut Tolerance after Early Peanut Introduction'
(2017). Allergy, 72 (8), 1267-71. http://dx.doi.org/10.1111/all.13127, PMID: 28691223
Lawson K, Bahnson HT, Sever M, Du Toit G, Lack G, Brittain E, Keet C, Greenhawt M, Fleischer D, Chan ES, Venter C, Stukus D, Gupta R, Spergel J
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Lawson K, Bahnson HT, Sever M, Du Toit G, Lack G, Brittain E, Keet C, Greenhawt M, Fleischer D, Chan ES, Venter C, Stukus D, Gupta R, Spergel J (2017). Letter of response to Greenhawt et al. 'LEAPing Through the Looking Glass: Secondary Analysis of the Effect of Skin Test Size and Age of Introduction on Peanut Tolerance after Early Peanut Introduction'. Allergy, 72 (8), 1267-71.
Looking behind the data curtain
(2017). Cell Immunol. http://dx.doi.org/10.1016/j.cellimm.2017.07.008, PMID: 28754194
Nepom GT, Scott D
[Reprint] [PubMed]
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Nepom GT, Scott D (2017). Looking behind the data curtain. Cell Immunol.
Mechanisms of Mixed Chimerism-Based Transplant Tolerance
(2017). Trends Immunol., 38 (11), 829-43. http://dx.doi.org/10.1016/j.it.2017.07.008, PMID: 28826941, PMCID: PMC5669809
Zuber J, Sykes M
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Zuber J, Sykes M (2017). Mechanisms of Mixed Chimerism-Based Transplant Tolerance. Trends Immunol., 38 (11), 829-43.
Immune Interventions to Preserve β Cell Function in Type 1 Diabetes
(2016). J Investig Med, 64 (1), 7-13. http://dx.doi.org/10.1097/JIM.0000000000000227, PMID: 26225763, PMCID: PMC4732932
Ehlers MR
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Ehlers MR (2016). Immune Interventions to Preserve β Cell Function in Type 1 Diabetes. J Investig Med, 64 (1), 7-13.
Strategies for clinical trials in type 1 diabetes
(2016). J Autoimmun, Jul (71), 88-96. http://dx.doi.org/10.1016/j.jaut.2016.03.008, PMID: 27068279, PMCID: PMC4903883
Ehlers MR
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Ehlers MR (2016). Strategies for clinical trials in type 1 diabetes. J Autoimmun, Jul (71), 88-96.
Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes
(2016). J Autoimmun, Jul (71), 44-50. http://dx.doi.org/10.1016/j.jaut.2016.02.009, PMID: 26948997, PMCID: PMC4903876
Buckner JH, Nepom GT
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Buckner JH, Nepom GT (2016). Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes. J Autoimmun, Jul (71), 44-50.
Clinical trial data access: Opening doors with TrialShare
(2016). J Allergy Clin Immunol. http://dx.doi.org/10.1016/j.jaci.2016.05.034, PMID: 27474121
Asare AL, Carey VJ, Rotrosen D, Nepom GT
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Asare AL, Carey VJ, Rotrosen D, Nepom GT (2016). Clinical trial data access: Opening doors with TrialShare. J Allergy Clin Immunol.
Prevention of food allergy
(2016). J Allergy Clin Immunol, 137 (4), 998-1010. http://dx.doi.org/10.1016/j.jaci.2016.02.005, PMID: 27059727
Du Toit G, Lack G, Tsakok T, Lack S
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Du Toit G, Lack G, Tsakok T, Lack S (2016). Prevention of food allergy. J Allergy Clin Immunol, 137 (4), 998-1010.
Solving the puzzle of autoimmunity: critical questions
(2015). F1000Prime Rep, 3 (7), 17. http://dx.doi.org/10.12703/P7-17, PMID: 25750735, PMCID: PMC4335798
Smilek DE; St Clair EW
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Smilek DE; St Clair EW (2015). Solving the puzzle of autoimmunity: critical questions. F1000Prime Rep, 3 (7), 17.
Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation
(2015). Sci Transl Med, 7 (280), 280rv2. http://dx.doi.org/10.1126/scitranslmed.aaa6853., PMID: 25810312, PMCID: PMC4425354
McDonald-Hyman C, Turka LA, Blazar BR
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McDonald-Hyman C, Turka LA, Blazar BR (2015). Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation. Sci Transl Med, 7 (280), 280rv2.
The Road Traveled: Genomics and Biomarkers in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
(2015). Arthritis Rheumatol, 67 (7), 1700-2. http://dx.doi.org/10.1002/art.39148, PMID: 25891203
Kimberly RP
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Kimberly RP (2015). The Road Traveled: Genomics and Biomarkers in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. Arthritis Rheumatol, 67 (7), 1700-2.
Targeting Memory T Cells in Type 1 Diabetes
(2015). Curr Diab Rep, 15 (11), 84. http://dx.doi.org/10.1007/s11892-015-0659-5, PMID: 26370695
Ehlers MR, Rigby MR
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Ehlers MR, Rigby MR (2015). Targeting Memory T Cells in Type 1 Diabetes. Curr Diab Rep, 15 (11), 84.
Tolerance signatures in transplant recipients
(2015). Curr Opin Organ Transplant, 20 (4), 400-5. http://dx.doi.org/10.1097/MOT.0000000000000207, PMID: 26107969, PMCID: PMC4524570
Newell KA, Turka LA
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Newell KA, Turka LA (2015). Tolerance signatures in transplant recipients. Curr Opin Organ Transplant, 20 (4), 400-5.
ABO-compatible liver allograft antibody-mediated rejection: an update
(2015). Curr Opin Organ Transplant, 20 (3), 314-24. http://dx.doi.org/10.1097/MOT.0000000000000194, PMID: 25944231, PMCID: PMC4646419
Demetris AJ, Zeevi A, O'Leary JG
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Demetris AJ, Zeevi A, O'Leary JG (2015). ABO-compatible liver allograft antibody-mediated rejection: an update. Curr Opin Organ Transplant, 20 (3), 314-24.
Is the use of epinephrine a good marker of severity of allergic reactions during oral food challenges?
(2015). J Allergy Clin Immunol Pract, 3 (3), 429-30. http://dx.doi.org/10.1016/j.jaip.2014.12.009, PMID: 25956314
Santos AF, Du Toit G, Lack G
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Santos AF, Du Toit G, Lack G (2015). Is the use of epinephrine a good marker of severity of allergic reactions during oral food challenges?. J Allergy Clin Immunol Pract, 3 (3), 429-30.
Crossing the Atlantic: the Euro-Lupus Nephritis regimen in North America
(2015). Arthritis Rheumatol, 67 (5), 1144-6. http://dx.doi.org/10.1002/art.39067, PMID: 25779381, PMCID: PMC4523131
Wofsy D, Diamond B, Houssiau FA
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Wofsy D, Diamond B, Houssiau FA (2015). Crossing the Atlantic: the Euro-Lupus Nephritis regimen in North America. Arthritis Rheumatol, 67 (5), 1144-6.
Tolerance: one transplant for life
(2014). Transplantation, 98 (2), 117-121. http://dx.doi.org/10.1097/TP.0000000000000260, PMID: 24926829, PMCID: PMC4101034
Kawai T, Leventhal J, Madsen JC, Strober S, Turka LA, Wood KJ
[PubMed]
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Kawai T, Leventhal J, Madsen JC, Strober S, Turka LA, Wood KJ (2014). Tolerance: one transplant for life. Transplantation, 98 (2), 117-121.
Transplantation: moving to the next level
(2014). Immunol Rev, 258 (1), 5-11. http://dx.doi.org/10.1111/imr.12161, PMID: 24517422, PMCID: PMC4038030
Sykes M
[Reprint] [PubMed]
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Sykes M (2014). Transplantation: moving to the next level. Immunol Rev, 258 (1), 5-11.
Immune-modulating effects of alpha-1 antitrypsin
(2014). Biol Chem., 395 (10), 1187-93. http://dx.doi.org/10.1515/hsz-2014-0161, PMID: 24854541, PMCID: PMC4237306
Ehlers MR
[Reprint] [PubMed]
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Ehlers MR (2014). Immune-modulating effects of alpha-1 antitrypsin. Biol Chem., 395 (10), 1187-93.
Targeted immune interventions for type 1 diabetes: not as easy as it looks!
(2014). Curr Opin Endocrinol Diabetes Obes, 21 (4), 271-8. http://dx.doi.org/10.1097/MED.0000000000000075, PMID: 24983393, PMCID: PMC4133939
Rigby MR, Ehlers MR
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Rigby MR, Ehlers MR (2014). Targeted immune interventions for type 1 diabetes: not as easy as it looks!. Curr Opin Endocrinol Diabetes Obes, 21 (4), 271-8.
Restoring the balance: immunotherapeutic combinations for autoimmune disease
(2014). Dis Model Mech, 7 (5), 503-13. http://dx.doi.org/10.1242/dmm.015099, PMID: 24795433, PMCID: PMC4007402
Smilek DE, Ehlers MR, Nepom GT
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Smilek DE, Ehlers MR, Nepom GT (2014). Restoring the balance: immunotherapeutic combinations for autoimmune disease. Dis Model Mech, 7 (5), 503-13.
Anti-cytokine therapies in T1D: Concepts and strategies
(2013). Clin Immunol, 14 (3), 279-285. http://dx.doi.org/10.1016/j.clim.2013.02.003, PMID: 23510726, PMCID: 3700624
Nepom GT, Ehlers M, Mandrup-Poulsen T
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Nepom GT, Ehlers M, Mandrup-Poulsen T (2013). Anti-cytokine therapies in T1D: Concepts and strategies. Clin Immunol, 14 (3), 279-285.