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Tetramer Core

Principal Investigator

William Kwok | Benaroya Research Institute | Seattle, WA

Abstract

MHC Class II tetramer reagents and staining procedures allow for the direct detection of antigen specific T cells by flow cytometry.

The Immune Tolerance Network MHC peptide tetramer core at Benaroya Research Institute in Seattle, WA, is being used to innumerate antigen specific T cells and class II-recognizing T cells (CD4 cells). At present the major application for this technology is for type 1 diabetes where we are looking at T cell responses to GAD65 antigen, some of the peptide antigens presumed to be involved in multiple sclerosis. Antigens implicated in other autoimmune diseases will also be investigated.

Principal Investigator

William Kwok | Benaroya Research Institute | Seattle, WA

Articles

Nepom, GT. (2003) MHC multimers: expanding the clinical toolkit. Clin Immunol, 106 (1), 1-4. PMID: 12584043 [PubMed] [Reprint]

The Immune Tolerance Network and is sponsored by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

National Institute of Allergy and Infectious Diseases

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