Tissue Pathology Core at UPMC

Principal Investigator

Anthony Demetris | University of Pittsburgh | Pittsburgh, PA


The Division of Transplantation Pathology at the University of Pittsburgh Medical Center offers a comprehensive consultation service in solid organ transplantation pathology to community and university based physicians. Dr. Anthony Demetris is the director of the Division of Transplantation Pathology and has served as the Immune Tolerance Network (ITN) core laboratory director for liver pathology analysis since 2003. More recently, Dr. Demetris' services were extended to performing kidney pathology evaluations for ITN kidney transplant trials.

The University of Pittsburgh Laboratory will conduct routine analysis on 3 active ITN liver transplant studies. Analyses will be performed on all biopsies requiring an evaluation of the amount of fibrosis. In addition to continuing routine analysis for liver transplant studies, The University of Pittsburgh Pathology Laboratory will provide analysis of renal allograft biopsies. Analysis of renal allograft biopsies will be very similar to liver allograft biopsies, but involves a different panel of stains routinely applied to kidney allograft.

Selected Publications:

Human Liver Allograft Acceptance Without Immunosuppression. How did we get here and where are we going?, University of Alberta, Alberta Transplant Lecture Series, Edmonton, Alberta, Canada, September 15, 2010.

Implementation and Validation of Clinical Whole Slide Imaging, Pathology Informatics 2010, Boston, MA, September 20, 2010.

How Does Portal Hyperfusion Cause Small-For-Size Syndrome, AASLD Annual Meeting, Boston, MA, October 30, 2010.

Prospective Evaluation of Histopathologic Biopsy Features that Predict Successful Weaning and Comparison to Protocol Follow-up Biopsies 2 Years After Complete Immunosuppression Withdrawal in Living-related Pediatric Liver Allograft Recipients, Oral Abstract Presentation as AASLD Annual Meeting, Boston, MA, October 31, 2010.

Chronic Rejection in CTA and SOT-Differences and Similarities, American Society for Reconstructive Transplantation 2nd Biennial Meeting, Chicago, IL, November 19, 2010.

Meeting Abstracts

Demetris AJ, Ruppert K, Ekong U, Rosenthal P, Sayre P, Tchao N, Feng S. Morphometric and Histopathologic Analysis of Protocol Biopsies from Stable, Long-Surviving Pediatric Recipients of Livi. (Abstract #909) American Transplant Congress, San Francisco, CA, May 5-9, 2007. [Abstract]