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January 19, 2012

ITN Study Published in JAMA Shows Successful Immunosuppression Weaning in Pediatric Liver Recipients

Results from an ITN study published today in the Journal of the American Medical Association demonstrated successful weaning of anti-rejection drugs in pediatric liver transplant recipients (results here).  Results from this multicenter pilot study, led by Sandy Feng, MD, PhD (University of California, San Francisco), suggest that certain children undergoing liver transplantation from a parental living donor may be able to maintain their organ without the burdens of lifetime immunosuppression.This study enrolled 20 highly-selected pediatri
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January 18, 2012

New ITN Oral Tolerance Pilot Study Enrolls First Patients

A new ITN pilot study to look at oral tolerance is now open and has enrolled its first subjects.  The pilot, led by Lloyd Mayer, MD (Mount Sinai) and called “Pilot study to determine the immunogenicity of Immucothel® and oral tolerance induction with Biosyn Native KLH in healthy subjects,” is a first step in investigating oral tolerance mechanisms and their role in autoimmunity. Oral tolerance refers to a regulatory immune response that arises from ingesting antigens orally.
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January 9, 2012

New Publication: Indirect Pathway T-cell Responses Reflect Outcomes in Kidney Transplant Recipients

In an ITN supported study recently published in American Journal of Transplantation a new potential indicator of clinical outcome in renal transplant recipients has been identified (results here). The signature was identified from samples collected under the ITN study, “ITN registry of tolerant kidney transplant recipients” led by Kenneth Newell, MD (results reported here).
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